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ea0081p464 | Thyroid | ECE2022

Steroid treatment in the management of destructive thyrotoxicosis induced by PD1 blockade

Brancatella Alessandro , Pierotti Laura , Lupi Isabella , Montanelli Lucia , Viola Nicola , Sgro Daniele , Sardella Chiara , Antonangeli Lucia , Brogioni Sandra , Cremolini Chiara , Marcocci Claudio , Santini Ferruccio , Latrofa Francesco

Objective: Destructive thyroiditis is the most common endocrine immune related adverse event (iRAEs) in patients treated with anti-PD1/PD-L1 agents. Given its self-limited course, current guidelines recommend no treatment for this iRAE. Nevertheless in patients with enlarged thyroid volume and a poor performance status, thyrotoxicosis may be particularly severe and harmful. Aim of the study is to evaluate if steroid treatment might be useful in improving thyrotoxicosis in subj...

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ea0070aep914 | Thyroid | ECE2020

Thyroid imaging in the management of anti-PD1/PD-L1 induced thyrotoxicosis

Brancatella Alessandro , Lupi Isabella , Viola Nicola , Sgrò Daniele , Antonangeli Lucia , Montanelli Lucia , Sardella Chiara , Brogioni Sandra , Ricci Debora , Bianchi Francesca , Piaggi Paolo , Santini Ferruccio , Marcocci Claudio , Latrofa Francesco

Context: Thyrotoxicosis is the most common endocrine adverse event due totreatment with anti-PD1 and anti-PD-L1. The most common form is destructive thyrotoxicosis whereas persistent, supposedly autoimmune hyperthyroidism (Graves’ hyperthyroidism) is rare. The possible role of thyroid imaging (neck ultrasound and scintigraphy) in the differential diagnosis has never evaluated.Aim: To evaluate the usefulness of neck ultrasound and 99Tc- s...

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Endocrine Abstracts

Steroid treatment in the management of destructive thyrotoxicosis induced by PD1 blockade

Thyroid imaging in the management of anti-PD1/PD-L1 induced thyrotoxicosis

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